Thursday, January 20, 2005

Closing in on Gay Genes

A new study has found several more interesting linkages between the human genome and sexual orientation. You can read the original paper from the journal Human Genetics HERE. The researchers' press release is a little lighter reading, probably more appropriate for a site like this:
CHICAGO, Illinois, USA, January 12, 2005— A new genetic study helps explain why some men are gay and other men are heterosexual. The first research project that examines linkage between male sexual orientation and genes across the human genome was published this month in the prestigious biomedical journal, Human Genetics. The culmination of several years of research, the report identified three new chromosomal regions of interest.

One hundred forty-six families that had two or more gay brothers participated in the study. The largest finding was a statistically suggestive linkage to a region on chromosome 7 called 7q36, and the second largest link was found on chromosome 8, in a region called 8p12. There was also an interesting finding on chromosome 10, in the region called 10q26, where the linkage to sexual orientation only occurred if that region was inherited from the mother. This is likely a result of the recently discovered phenomenon that geneticists call "genomic imprinting." Given the complex nature of sexual orientation it is not surprising that multiple genetic regions were implicated.

According to the lead author of the study, Dr. Brian Mustanski, "Our study helps to establish that genes play an important role in determining whether a man is gay or heterosexual. It expands upon previous research with twins, which has consistently found evidence for genetic influences on sexual orientation. The next steps will be to see if these findings hold up in a new sample and then identify the particular genes within these newly discovered chromosomal regions." Dr. Mustanski emphasized that finding the specific genes would have implications beyond uncovering the cause of homosexuality. Their identification would also greatly advance our understanding of human variation, evolution, and brain development. Press Release

In a separate FAQ document, the lead author answers the question: Did you find the "gay gene?"

His answer:
For several reasons the answer to this question is no. First, sexual orientation is such a complex phenotype that no one gene could ever explain it. Instead, our best guess is that multiple genes, acting and interacting with environmental influences, explain variability in sexual orientation. Therefore, a better question is, "did you find one of the genes that influence male sexual orientation?"

He also answers the question, Does your study prove that homosexuality is genetic?
We found 3 new chromosomal regions that showed some linkage to male sexual orientation. This suggests that within these chromosomal regions are genes that influence male sexual orientation. If genes did not influence male sexual orientation it is unlikely that we would have found linkage to these regions. Our study builds upon previous twin and family studies which have consistently found evidence for genetic influences on sexual orientation. As with all scientific research, it is important that our results are replicated in another lab with a new sample of participants to guarantee that they are not due to unlikely random chance. At this point, the best evidence suggests that genes play an important role in determining if a man is gay or heterosexual.

Anti-gay groups have frequently argued that there is no gay gene. It seems that the implication is that people can choose their sexual orientation, since it's not hard-wired at conception. In that light, it is interesting to learn from these researchers about twin and family studies which have consistently found evidence for genetic influences on sexual orientation. We would not expect to find one site on the chromosome that explains all variation in sexual orientation, but these researchers have narrowed it down to a small number of locations. This is a young science, we can be sure that more will be learned as time rolls along.


Blogger Unknown said...

This is your proof? There's stronger proof that alcoholism is genetic.

And please show me where the MCPS Curriculum group has said that homosexuality is just a choice.

You put up straw men all day here, don't you?

January 25, 2005 2:37 PM  
Blogger JimK said...

Where they say it? Let's start with the Washington Times, this morning. Story lead: "Critics of a new sex-education curriculum in Montgomery County public
schools say the program teaches that homosexuality is not a choice without including scientific information to the contrary."

The idea that gays can change is fundamental to the recall group's criticism of the curriculum. They want to include a bunch of stuff about that. There is no scientific support for the idea, and in fact almost all psychotherapy and counseling organizations have declared it unethical to try to get homosexuals to become straight.

And as far as evidence that alcoholism is genetic, mmm, yeah, you're right. Heart disease, too, hemophilia, hair color ... what was your point?

January 26, 2005 3:03 PM  
Anonymous Anonymous said...

Um, Jim. Can you quote one member of the CRC saying that?

I sympathize with them (obviously) and agree that the new curriculum is crap, but I fully concur that there may be genetic markers for homosexuality. That doesn't mean I want children told that having erotic same-sex play in early childhood is a spiffy thing to do. Just as I don't think that encouraging alcoholism is the right thing to do just because it's got genetic markers as well.


January 26, 2005 5:07 PM  
Blogger JimK said...

Imagine a class that said, "X percent of the population are alcoholics." Do you think that would make the kids in the class real thirsty for a big jug o' moonshine? Would you object to that being taught? I doubt it. But booze is actually bad for you.

So now they'll have a class where they say, "X percent of adolescents engage in some same-sex play." Now you interpret that to mean that same-sex play is ... what'd you say? "Spiffy?" And you're sure that the mere mention of such activity will make kids want to do it.

Remember being twelve or thirteen, sitting in class. Do you really think that if a teacher had said something like this in class, it woulda made you want to run into the woods with your buddies and try this stuff?

I mean, come on, man, that's nuts.

January 27, 2005 4:28 PM  

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